Protective effect of garlic polysaccharide on cardiac myocyte injury by adriamycin
- VernacularTitle:大蒜多糖对阿霉素所致心肌细胞损伤的保护作用
- Author:
Wei YU
;
Jiliang WU
;
Hui WANG
;
Wenliang ZHA
- Publication Type:Journal Article
- Keywords:
garlic polysaccharide;
adriamycin;
cardiac myocyte;
flow cytometry
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the protective effects and its mechanisms of Garlic Polysaccharide(GP) on toxic cardiac myocyte induced by adriamycin (ADR). Methods Primary culture neonatal SD rat cardiac myocyte and ADR injury model were established. The activities of several superior fluid and cells enzymes were measured. Using MTT assay and flow cytometry, the apoptotic cardiac myocyte was shown. Results ADR increased the superior fluid creatine kinase (CK), lactate dehydrogenase(LDH), glutamic oxaloacetic transaminase (GOT), and augmented myocardial malondialdehyde (MDA) content, while decreased the superoxide dismutase (SOD) activities (P
