Role of peripheral NMDA receptor in pain occurrence and management
- VernacularTitle:外周NMDA受体在疼痛发生及药物干预中的作用
- Author:
Xuerong YU
;
Yuguang HUANG
- Publication Type:Journal Article
- Keywords:
NMDA receptor;
peripheral;
pain occurrence;
pain management
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
NMDA(N-Methyl-D-Aspartate)receptor is a kind of ionotropic receptors, which have been widely localized in peripheral somatic tissues and visceral pain pathways. The activation or expression changes of peripheral NMDA receptor may play an important role in pain occurrence. Peripheral administration of NMDA receptor antagonist can alleviate or prevent pain and enhance the analgesic effect of opiate. This method of administration can reduce the side effect of central action induced by the drug. It will be an important research direction of pain management.
