Protection effect of baicalin on isoproterenol induced myocardial ischemia in rats
- VernacularTitle:黄芩苷对异丙肾上腺素诱导大鼠心肌缺血的治疗作用
- Author:
Jian LU
;
Xiaodong WU
- Publication Type:Journal Article
- Keywords:
baicalin;
isoproterenol;
myocardial ischemia;
TNF-?;
p38mapk
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the protection effect of baicalin on isoproterenol (ISO) induced myocardial ischemia in rats and its mechanisms. METHODS: Forty-five Sprague-Dawley rats were randomly divided into 3 groups. The rats in control group (n=15) received no treatment. The rats in ISO group (n=15) received two times of subcutaneous injection of ISO (20 mg?kg~ -1), which was separated by a 24 hours-interval. The rats in baicalin group (n=15) received ISO as described above and received baicalin 50 mg?kg~ -1 ip. simultaneously. Two days later the hemodynamic measurement was performed and the serum levels of LDH, CK and TNF-? were detected. The expression of p38mapk in myocardium was detected by immunohistochemical technique. RESULTS: The heart function of the group treated with baicalin was improved significantly compared with that of control group. The levels of LDH, CK and TNF-? in baicalin group decreased significantly compared with those in control group and the expression of p38mapk in myocardium also decreased markedly. CONCLUSION: Baicalin has protection effect on isoproterenol induced myocardial ischemia in rats, and the effect maybe due to the decrease of TNF-? induced by reducing the p38mapk expression.
