Study on annexinⅡ expression in differentiation of human epidermal keratinocyte
- VernacularTitle:AnnexinⅡ在已分化人表皮角质形成细胞中表达的研究
- Author:
Xiling LI
;
Xiaohua LIAN
;
Li YANG
;
Tian YANG
- Publication Type:Journal Article
- Keywords:
annexinⅡ;
tissue-type plasminogen activator;
keratinocyte;
differentiation;
human embryo;
adult
- From:Journal of Third Military Medical University
2003;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the annexinⅡexpression in the differentiation of human epidermal keratinocytes. Methods Immunohistochemistry was used to detect annexinⅡexpression in early, middle, late human embryonic skin and adult skin, respectively. Results The expression of annexinⅡ in embryonic epidermis was significantly increased with the development of embryo and annexin Ⅱ expressed much higher in adult epidermis than in embryonic epidermis. Annexin Ⅱ localized in the membrane of keratinocyte, mainly in suprabasal, the more differentiated layers of the epidermis. Conclusion Annexin Ⅱ may be involved in regulating the differentiation of human epidermal keratinocytes.
