Relationship between proliferation of prostate cancer cells and androgen receptor expression
- VernacularTitle:前列腺癌AR表达与细胞增殖的关系
- Author:
Xinwei DIAO
;
Mingfu YE
;
Zaigen ZHANG
;
Yali WANG
- Publication Type:Journal Article
- Keywords:
prostate cancer;
androgen receptor;
proliferating cell nuclei antigen;
Ki67;
NORs;
epidermal growth factor receptor
- From:Journal of Third Military Medical University
2003;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between proliferation activity-related factors and androgen receptor (AR) expression in 113 cases of human prostate cancer (PCa). Methods AR and the proliferation activity-related factors (PCNA, Ki67, EGFR) in PCa were detected by immunohistochemistry and light/(electron) microscopy. Results Cell proliferation in AR-negative groups of PCa was significantly stronger than in AR-positive groups. Conclusion AR aberrant expression may promote proliferative ability of PCa, cell growth and heterogeneity significantly, which may be one of reasons that PCa is difficult to be cured.
