Concurrent chemoradiation therapy with cisplatin and paclitaxel for locally advanced non-small cell lung cancer
- VernacularTitle:紫杉醇和顺铂同步放化疗治疗局部晚期非小细胞肺癌的临床分析
- Author:
Ping ZHANG
;
Shixiu WU
;
Congying XIE
- Publication Type:Journal Article
- Keywords:
Carinoma,non small cell lung/radiotherapy;
Carinoma,non small cell lung/chemotherapy;
Combined modality therapy;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2005;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of concurrent systemic routine dose of paclitaxel/ cisplatin combined with conventional thoracie irradiation in locally advanced non-small cell lung cancer(NSCLC).Methods Forty-two unresectable stage ⅢA and ⅢB NSCLC patients were entered into this study.All patients received conventional thoracic irradiation to a total dose of 60Gy within 6 weeks,with concurrent paclitaxel 135mg/m~2,d1,and cisplatin 75mg/m~2 in the first and fourth week of radiotherapy.Results The complete response(CR) and partial response(PR) was 2/42,and 30/42 patients,with an overall response rate of 76.2% and a median survival time of 18 months.The 1-,2-,and 3-year survival rate was 64.3%,30.2%,12.0%,respectively.The 1-,2-,and 3-year progression-free survival rates was 48.1%,21.4%,5.7%,with a median progression-free survival of 12 months.Fourteen patients failed only locoregionally,10 in distant metastastasis only and 5 in both.The locoregional/distant failure rate was higher in stageⅢB than in stage ⅢA(P
