Clinical and pathological characteristics of primary biliary cirrhosis(PBC) and autoimmune hepatitis(AIH) overlap syndrome:an analysis of 11 cases
- VernacularTitle:原发性胆汁性肝硬化自身免疫性肝炎重叠综合征临床病例分析
- Author:
Chunping WANG
;
Yongping YANG
;
Xuemei MA
- Publication Type:Journal Article
- Keywords:
liver cirrhosis, biliary;
hepatitis, autoimmune;
overlap syndrome
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical and pathological features and responses to therapy of primary biliary cirrhosis(PBC) and autoimmune hepatitis(AIH) overlap syndrome. Methods Comparison was made between 11 patients with PBC/AIH overlap syndrome, 21 cases with type I AIH and 20 cases with PBC (Scheuer stage Ⅰ and Ⅱ), and the emphases was laid upon the clinical manifestations, pathological features and responses to therapy of the patients with PBC/AIH overlap syndrome. Results No significant differences were found in sex, age and course of diseases among the three groups. In PBC/AIH group, the serum levels of alkaline phosphatase (AKP), ?-glutamyl-transpeptidase (GTP), IgM and the frequency of positive anti-mitochondrial antibodies (AMA) and AMA-M2 antibodies were significantly higher than those in the pure AIH group(P
