The use of magnifying chromoendoscopy in early detection of gastric cancer and its precancerous lesions
- VernacularTitle:放大色素内镜诊断早期胃癌及其癌前病变
- Author:
Lei CHEN
;
Dianchun FANG
;
Xianghong LI
- Publication Type:Journal Article
- Keywords:
magnifying chomoendoscopy;
pit patterns;
mucosal atrophy;
intestinal- metaplasia;
dysplasia;
early gastric cancer
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the pit patterns of mucosal atrophy, intestinal metaplasia, dysplasia of gastric mucosa and early gastric cancer by magnifying chromoendoscopy. Methods The pit patterns of gastric mucosa of 594 patients with gastrosia were observed with electronic magnifying endoscopy (Olympus GIF Q-240Z) assisted with methylene blue staining. Biopsies were taken from suspicious sites as observed after magnification for histopathologic examination. Results The diagnostic sensitivity, specificity and accuracy of magnifying chromoendoscopy for mucosal atrophy were 74.6%, 90.4% and 84.1%, respectively. In the central part of mild atrophic areas gastric pits were found to be decreased in quantity or even disappeared, while in severe atrophic area, scar-like changes were seen due to the disappearance of pits, with elongation and tortuosity of surrounding. Mucosa with intestinal metaplasia was lightly stained by methylene blue, and pit patterns appeared as villi, scars or coarse lines. Mucosa of dysplasia or early gastric cancer was heavily stained by methylene blue, and gastric pits were amorphous and irregular in size. Conclusion Gastric mucosal atrophy, intestinal metaplasia, dysplasia and early gastric cancer have their peculiar pit patterns, and magnifying chomoendoscopy may be useful in the diagnosis of these lesions.
