The effect of resveratrol on vasodilatation of abdominal aorta in rat and its underlying mechanism
- VernacularTitle:白藜芦醇对大鼠腹主动脉的舒张作用及其机制
- Author:
Min SHEN
;
Haichang WANG
;
Heng MA
- Publication Type:Journal Article
- Keywords:
resveratrol;
aortic artery;
vasodilatation
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the functional features of resveratrol on vasodilatation of abdominal aorta in rat and its underlying mechanism. Methods Isolated aortic ring was perfused and the tension of the vessel was measured. Results Resveratrol showed a dose-dependent relaxant effect on rat aorta at 4?10 -9～4?10 -5mol/L. At the concentration of 4?10 -5mol/L, the effect was attenuated by (74.9?1.9)% in the endothelium removal group, and it was significantly different from the control group (P0.05). At the concentration of 7?10 -5mol/L, resveratrol showed an relaxant effect on de-endothelium vessels. Conclusion Resveratrol relaxes the aorta in both endothelium dependent and independent manner. In the endothelium-dependent manner, the mechanism of vasodilatation may be associated with NO system and KATP channel, while in the endothelium-independent manner effect of resveratrol might be a direct one.
