The signal pathways involved in the effects of thyroid stimulating antibody on the secretory function of thyrocytes
- VernacularTitle:甲状腺刺激抗体对甲状腺细胞分泌功能影响的信号途径
- Author:
Jianrong LI
;
Guoliang HUANG
;
Libin LIU
- Publication Type:Journal Article
- Keywords:
Thyroid stimulating antibody Thyrocyte function Signal pathway Graves' disease
- From:
Chinese Journal of Practical Internal Medicine
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the signal pathways involved in the effects of thyroid stimulating antibody(TSAb)on the secretory function of cultured thyrocytes.Methods (1)With the method of enzyme-linked immunosorbent assay (ELISA),the PKA and PKC activities were observed.(2)Inhibitors or activators of protein kinases (PKA and PKC) were used to activate or block the signal pathways and the secretion of T3 measured by radioimmunoassay.Results (1)TSAb activated both PKA and PKC in thyrocytes in a dose-,time-dependent manner(.P.
