Effect of rhGH on rat model of postoperative fatigue
- VernacularTitle:重组生长激素对手术后疲劳综合征大鼠模型的影响
- Author:
Jianxin YANG
- Publication Type:Journal Article
- Keywords:
postoperative fatigue syndrome;
animal model;
rat;
gene expression;
rhGH
- From:Journal of Third Military Medical University
2003;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of rhGH on rat model of postoperative fatigue syndrome (POFS) and to study its mechanism. Methods A total of 36 SD rats were randomly divided into 3 groups. The model group and rhGH group were estalished into the model of POFS by partial resection of the liver, and administrated with the same volume of physiological saline and rhGH, and control group was without any treatment. The behavioral changes and the disorder of nutrition intake after operation, stress reaction (pathological changes of mucous membrane in small intestine) and the liver albumin expression were observed. Results The rhGH could improve behavioral changes of rat model and increase the serum levels of the iron, total protein, albumin and globulin as the index of nutrition, and restore the injury of the mucous membrane resulted from the stress reaction and increase the expression of the liver albumin. Conclusion rhGH can shorten the time of POFS and mitigate POFS of rat model.
