Study of gene expression variation of rat kidney ugt1a6 related to propofol metabolism in anhepatic phase
- VernacularTitle:大鼠肾脏异丙酚代谢相关ugt1a6基因在无肝期表达变化的研究
- Author:
Jianteng GU
- Publication Type:Journal Article
- Keywords:
propofol;
uridine diphosphate glucuronyltransferase;
anhepatic phase;
gene
- From:Journal of Third Military Medical University
2003;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the gene expression variation of rat kidney uridine diphosphate glucuronatetransferase ugt1a6 related to propofol metabolism in anhepatic phase and to primarily explain the reasons of extrahepatic metabolism characteristic of propofol. Methods A total of 15 male SD rats were distributed randomly to 3 groups (n=5 in each group): control group (group A), devascularization of the hepatic portal for 30 min (group B) and 60 min (group C). Kidney tissues of rats were taken and ugt1a6 mRNA were detected by RT-PCR. Results Gene expression levels of kidney ugt1a6 of groups B and C were significantly higher than group A (P
