Advances in studies on lipoxygenase and its inhibitors
- VernacularTitle:脂加氧酶及其抑制剂研究进展
- Author:
Liping JIANG
;
Yang LU
;
Hongzhuan CHEN
- Publication Type:Journal Article
- Keywords:
lipoxygenase;
lipoxygenase inhibitors;
cardiovascular diseases;
target
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Lipoxygenase(LO) pathway had been implicated in the pathogenesis of such cardiovascular diseases as hypertension, atherosclerosis, restenosis, and palys and important role in the development of these disease. LO inhibitiors could suppress vascular contractile responses significantly, reduce blood pressure, inhibit migration of vascular smooth muscle cells(VSMC), attenuate neointimal thickening in the injuried arteries and generation reactive oxygen species(ROS), block monocyte binding to VSMC, etc. The effects of LO inhibitors were associated with marked inhibition of MAPK pathway. Therefore, inhibition of LO pathway may provide a new strategy for preventing and treating above diseases, suggesting that LO mat be a novel taget for such purposes.
