Anti-inflammatory mechanism of non-steroidal anti-inflammatory drugs
- VernacularTitle:NSAIDs抗炎作用机制研究进展
- Author:
Bin ZHANG
;
Guanhua DU
- Publication Type:Journal Article
- Keywords:
non-steroidal anti-inflammatory drugs;
cyclooxygenase;
transcription factor;
protein kinase;
iNOS;
PPAR?
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
The anti-inflammatory mechanism of non-steroidal anti-inflammatory drugs (NSAIDs) is mainly due to inhibition of COX-2 activity. NSAIDs can also inhibit COX-2 expression and produce anti-inflammatory effect independent of COX. These COX-independent mechanisms include inhibiting transcription factors such as NF-?B and AP-1, interfering with signal transduction pathways through actions on Erk、p38MAPK、IKK and RSK2, activating PPAR? and HSF-1, inhibiting iNOS and transport of prostanoids from their generating cells.
