Progress in the study on D-serine in CNS
- VernacularTitle:D-丝氨酸在中枢神经系统的作用研究进展
- Author:
Sheng YANG
;
Wenxia ZHOU
;
Yongxiang ZHANG
- Publication Type:Journal Article
- Keywords:
D-serine;
NMDA receptor;
glia
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
D-amino acids were believed to have no function in higher organisms several years ago. Recently, D-serine was proved to be synthesized by astrocytes in vivo and be released to work as an effective coagonist at the “glycine-binding” site of the N-methyl-D-aspartate (NMDA) glutamate receptors in central nervous system. In this paper, the synthesis, metabolism and function of D-serine were reviewed briefly.
