Expression of VEGF, COX-2 mRNA in esophageal cancer
- VernacularTitle:VEGF、COX-2 mRNA在食管癌中的表达及其意义
- Author:
Jianhong LIAN
;
Chunli WANG
;
Guoping WANG
;
Simeng WANG
;
Weilan LIU
;
Sutang GUO
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Vascular endothelial growth factors;
Cyclooxygenase 2
- From:
Cancer Research and Clinic
2008;20(7):454-455,459
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of VEGF isoforms, COX-2 in esophageal cancer Methods VEGF, COX-2 mRNA expression in 40 paired samples (tumor and adjacent normal tissue) were determined by using real time RT-PCR. Results VEGF165 was overexpressed in 25 of 40(62.5 %) tumor tissues compared with in 6 of 40 (15 %) adjacent normal tissue; COX-2 was overexpressed in 28 of 40(70 %) tumor tissues compared with in 5 of 40(12.5 %) adjacent normal tissue. Conclusion This result suggests that VEGF165 and COX-2 overexpression in esophageal cancer.
