Effects of Xinnaoshenkang on cerebral ischmia injury of rats and its mechanism
- VernacularTitle:心脑肾康对脑缺血的干预作用及机制探讨
- Author:
Gang LIANG
;
Jie JIAN
;
Linquan ZANG
;
Zhiming HUANG
;
Zhengkai WEI
;
Jiangchun HUANG
- Publication Type:Journal Article
- Keywords:
XNSK;
cerebral ischmia-reperfusion injury;
protective effects
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the protective effects of Xinnaoshenkang (XNSK) against focal cerebral injury caused by ischmia-reperfusion in rats and its mechanism. Methods The focal brain ischmia-reperfusion model in rats was made through by using an intraluminal monofilament to occlude the middle cerebral artery for 1.5 h and then reperfusing for 24h.Spectrophotometric assay was used to measure the contents of malondial-dehyde (MDA), lactic acid (LA),superoxide dismutase(SOD), reactive oxygen species(ROS), nitricoxide synthase(NOS) and several ATPase in cerebral cortex homogenates from rats. The effects on platelet aggregation were also observed. Results Compared with model and positive control groups,88,175,350 mg?kg-1 XNSK groups were found having significant inhibition of cerebral infarction,MDA,LA,ROS,NOS,platelet aggregation and significant increase of the activity of SOD,ATPase. Conclusion XNSK has protective effects against focal cerebral injury caused by ischmia-reperfusion in rats.
