The effects and mechanism of safflor yellow on myocardial ischemia
- VernacularTitle:红花总黄素对缺血心肌的影响及机制研究
- Author:
Weichao ZHENG
;
Duobao CHEN
;
Lei ZHANG
;
Bing LI
- Publication Type:Journal Article
- Keywords:
safflor yellow;
myocardial ischemia;
coronary artery flux;
hemodynamics
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the effects and mechanism of safflor yellow on the experimental acute myocardial ischemia (AMI) model rats. Methods AMI model rats were induced by isoproterenol (10 mg?kg-1). The changes of indexes on hemodynamics such as MBP, LVSP, LVEDP and ?dp/dt_ max,the coronary artery flux(CF) and myocardia O_2 comption(MVO_2) in AMI model rats were observed respectively. Results The CF and MVO_2 in the heart muscle increased and decreased respectively the indexes of hemodynamics were improved in safflor yellow groups. Conclusion The results indicate that safflor yellow can inhibit the failure of heart function induced by AMI, increase the coronary artery flux and decrease MVO_2 significantly.
