Effects of sodium nitroprusside on glutamate-induced responses of supraoptic nucleus neurons in vitro
- VernacularTitle:硝普钠对离体视上核神经元谷氨酸反应的影响
- Author:
Hongping HUANG
;
Mengya WANG
- Publication Type:Journal Article
- Keywords:
sodium nitroprusside;
supraoptic nucleus;
nitric oxide;
glutamate;
electrophysiology
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To realize the modulatory actions of nitric oxide(NO) on supraoptic nucleus(SON)neurons by observing the effects of NO donor sodium nitroprusside(SNP) on the SON neurons. Methods The cell electrophysiology properties were obtained by the intracellular recording techniques from the SON neurons in adult rat hypothalamic slices. Results Local pressure ejection of glutamate induced depolarizing responses with decrease of input resistance, concentration- and membrane potential-dependent properties in 12 SON neurons. The amplitude and duration of glutamate responses were suppressed by bath of SNP in 67% of tested cells(P
