Anti-oxygen free radicals and anti-lipoperoxidation of nicotinic acid on hyperlipodemia quail
- VernacularTitle:烟酸抗高脂血症鹌鹑氧自由基和脂质过氧化作用
- Author:
Xuhui YANG
;
Jianhui MA
;
Minheng ZHU
;
Liyan LI
;
Yue WU
- Publication Type:Journal Article
- Keywords:
nicotinic acid (NA);
malondialdehy de (MDA);
superoxide dismutase (SOD)
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the oxygen free radical scavenging activities and antilipid peroxidation of nicotinic acid. Methods High lipid models of quail were induced by high fat diet. Five groups were divided, namely control group, high lipid group, NA group(150 mg?kg-1 and 75 mg?kg-1), and Vit E group (100 mg?kg-1). The contents of TC,TG,MDA and activities of SOD were examined for 3 times in the plasma and liver after administering NA for 9 weeks. Results The results showed the increase of TC,TG and MDA contents and decrease of SOD activities in high lipid groups by 3 weeks high fat diet. After administering NA for 3 weeks, NA reduced TC,TG and MDA contents and increased SOD activities, revealing the relationship to dose-dependence. Conclusion NA is most likely to possess the capabilities of anti-oxygen free radicals and anti-lipoperoxidation to hyperlipodemia quail.
