Protective effects of dihydrolycorine on hypoxia/reoxygenation injury in cultured neonatal rat cardiomyocytes
- VernacularTitle:二氢石蒜碱对大鼠乳鼠培养心肌细胞缺氧/复氧损伤的保护作用
- Author:
Shiqin JIANG
;
Peili GONG
- Publication Type:Journal Article
- Keywords:
dihydrolycorine;
cardiomyocyte;
hypoxia/ reoxygenation
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the protective effects of dihydrolycorine on hypoxia/reoxygenation (H/R) injury in cultured neonatal rat cardiomyocytes. Methods The hypoxia/ reoxygenation injury model of cultured neonatal rat cardiomyocytes was developed. The cell livability, the activity of lactate dehdrogenase (LDH) and superoxide dismutase (SOD), and the content of malondialdehyde (MDA) were determined in the cultured neonatal rat cardiomyocytes injured by H/R. Results Compared with normal group, the cell livability and the SOD activity of model group were decreased respectively, whereas the activity of LDH and the content of MDA of model group were increased significantly (P
