Effects of metformin on endocrine function of the pitutary-gonad axis in rats
- VernacularTitle:二甲双胍对大鼠垂体—性腺轴内分泌功能的影响
- Author:
Bai KANG
;
Peng DUAN
;
Guangzhou LI
;
Huirong HAN
- Publication Type:Journal Article
- Keywords:
metformin;
endocrine function;
pituitary-gonad axis;
ultramicrostructure
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effects of Metformin (MF) on endocrine function of pituitary-gonad axis in rats. Methods The serum hormone concentration was measured with radioimmunoassay (RIA) and the morphology of gonad endocrine cells was observed with electron microscope. Results MF(135 mg?kg-1?d-1,ig,14 d)decreased serum T concentration in male rats and serum LH concentrations in female rats significantly(P
