Effects of moxonidine on hemodynamics in anesthetized rats
- VernacularTitle:莫索尼定对麻醉大鼠血流动力学的影响
- Author:
Wei ZHANG
;
Jiliang XU
;
Jinhua HUANG
- Publication Type:Journal Article
- Keywords:
moxonidine;
blood pressure;
hemodynamics;
clonidine
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate effects of moxonidine on hemodynamics in anesthetized rats. Methods The indexes of hemodynamics were examined by catheterization of arteries in anesthetized Wistar rats. Results DBP, +dp/dt_ max, -dp/dt_ max,t-dp/dt_ max ,V_ pm and V_ max were significantly declined in dose-dependent manner after administration, but HR and SBP didn't change significantly. Conclusion These results showed that antihypertensive effects of moxonidine were related to inhibition of systolic and diastolic functions of myocardium.Furthermore,the antihypertensive effects of moxonidine were associated with reduction of peripheral vascular resistance.
