Molecular mechanism and prevention of gastric carcinogenesis
- VernacularTitle:胃黏膜癌变分子机制及防治研究
- Author:
Dianchun FANG
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
molecular mechanisms;
prevention and treatment
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer is a result of interaction of multiple factors. In previous studies it was found that genetic instability, abnormality of DNA methylation, telomere loss, mismatch of repair gene and k-ras mutation, loss of heterozygosity (LOH) of some of cancer-inhibitory genes such as APC, MCC and DCC, disbalance between cell proliferation and apoptosis, etc. were associated with the development of gastric cancer. It was also discovered that tretinoin, sodium selenite, sodium butyrate and epigallocatechin-3-gallate (EGCG) may be effective in preventing gastric carcinoma and gene therapy may partially reverse the malignant phenotype of gastric cancer cells.
