Expression of Bcl-2 of peripheral T, B lymphocytes in patients with liver fibrosis
- VernacularTitle:不同肝纤维化分级患者外周血T、B淋巴细胞Bcl-2的表达
- Author:
Ji LI
;
Yu ZHENG
;
Yongping CHEN
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Apotosis;
Genes, Bcl-2;
Lymphocytes
- From:
Chinese Journal of Infectious Diseases
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate Bcl-2 expression in the peripheral blood mononuclear cells and its clinical significance of liver fibrosis (LF). Methods Tested Bcl-2 protein levels in T, B cells of 47 patients (male 17, female 30) with LF, 35 patients (male 24, female 11) with chronic hepatitis B and no LF and 41 cases (male 29, female 12) normal controls by two color cytofluorography. Results Among them, LF patients, chronic hepatitis B without LF and normal controls, the proposition of T cells (including CD3~+, CD4~+ and CD8~+ subgroups) and CD19~+ B cells expressed Bcl-2 protein increased significantly in LF patients (P
