EFFECTS OF VITAMIN C ON THE ELECTROPHYSIOLOGICAL PROPERTY OF MYOCARDIAL CELLS OF THE RATS FED WITH LOW SELENIUM AND HIGH CADMIUM FODDER
- VernacularTitle:维生素C对低硒高镉饲料饲养大鼠心肌细胞电生理的影响
- Author:
Yaokui DUAN
;
Wenhua CAO
;
Aiguo LI
;
Liang XU
;
Xijun SONG
- Publication Type:Journal Article
- Keywords:
selenium;
cadmium;
vitamin C;
electrophysiology of myocardial cell
- From:
Acta Nutrimenta Sinica
1956;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effects of vitamin C(VC)on the electrophysiological property of myocardial cells of the rats fed with low selenium and high cadmium fodder. Method: Eight groups of rats were fed separately with: normal (2 groups), high Cd, high Cd+high VC, low Se+high Cd, low Se+high Cd+high VC, high Se+high Cd and high Se+high Cd+high VC fodder for 14 w. With intracellular microelectrode technique, the electrophysiological changes of rats were observed. Results:Compared with the control, there were no changes in high Cd+high VC group and in high Se+high Cd+high VC group. However,in high Cd group, RP and APA decreased, APD50 and APD90 prolonged; in low Se+high Cd group ,RP and APA decreased, APD50 and APD90 prolonged significantly; in low Se+high Cd+high VC group and high Se+high Cd group, though RP still decreased, no change had been detected on APA and APD. Conclusion: Se deficiency and simultaneous Cd overabundance may change the electrophysiological properties of myocardial cells of the rats significantly. However, VC may protect myocardial cells against the injury effectively.
