The effects of sulindac on the pathology of colorectal remnant polyps of familial adenomatous polyposis (FAP) patients
- VernacularTitle:舒林酸对家族性腺瘤性息肉病结直肠残存腺瘤组织病理学表现的影响
- Author:
Jun LI
;
Yumin LV
;
Zhu JIN
;
Rongli CUI
- Publication Type:Journal Article
- Keywords:
Sulindac;
Adenomatous polyposis coli;
Biopsy
- From:
Journal of Peking University(Health Sciences)
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the long-term effectiveness of sulindac on the pathology of colorectal adenomas of familial adenomatous polyposis (FAP) patients. Methods: FAP patients were treated with sulindac 400 mg per day. The change of colorectal polyps was assessed every 3 months in the first year. After the significant regression of colorectal polyps was achieved, sulindac was used to maintain the effects. The patients received colonoscopy examination regularly. Biopsies of remnant polyps and other lesions were obtained. The type and dysplasia grade of biopsies were evaluated and compared with baseline. Results: Before the study, 90.8% of adenoma biopsies were tubular, while 9.2% was tubulovillous adenoma. The dysplasia of grades Ⅰ, Ⅱ and Ⅲ were 42.1%, 45.6% and 12.3%, respectively. After sulindac treatment, 99.8% of adenoma biopsies were tubular, while 0.2% tubulovillous adenoma. There was significant difference compared with baseline (P
