Effects of low molecular weight heparin on vascular endothelial growth factor expression of early diabetic nephropathy
- VernacularTitle:低分子质量肝素对糖尿病肾病大鼠肾血管内皮生长因子表达的影响
- Author:
Liangying GAN
;
Zhongyuan YU
;
Meishun CAI
;
Huiping ZHAO
;
Xin LI
- Publication Type:Journal Article
- Keywords:
Heparin, low-molecular-weight;
Diabetic nephropathies;
Vascular endothelial growth factor;
Rats
- From:
Journal of Peking University(Health Sciences)
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of low molecular weight heparin(LMWH) on vascular endothelial growth factor(VEGF) expression of early diabetic nephropathy. Methods: Ninety-five male SD rats were randomly divided into three groups: normal control rats, STZ-induced diabetic rats and diabetic rats treated with LMWH. The renal tissues were subjected to immunohistochemical staining after 1,2,4,6,and 8 weeks’ treatment respectively to quantify the VEGF expression. Results: Immunohistochemical staining demonstrated an increasing in VEGF positive cells in diabetic rats. It was found that there were significant differences in VEGF staining intensity between diabetic rats and normal control rats and between LMWH treated rats and untreated diabetic rats after two weeks treatment. Conclusion: The inhibition of VEGF expression may be one of the mechanisms of LMWH’s renal protective effects on early diabetic nephropathy.
