Comparison of effect of DEET with different concentrations in prevention of Schistosoma japonicum infection in mice
- VernacularTitle:不同浓度DEET软膏制剂对小鼠日本血吸虫感染防护效果比较
- Author:
Haizhu ZHANG
;
Hongbin REN
;
Mingzhu SHI
;
Yuanchun FENG
;
Shiguo LIU
- Publication Type:Journal Article
- Keywords:
N,N-diethyl-m-toluamide (DDET);
Concentration;
Schistosoma japonicum;
Prevention
- From:
Chinese Journal of Schistosomiasis Control
1989;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the efficiency of N,N-diethyl-m-toluamide (DEET) with different concentrations in prevention of Schistosoma japonicum infection in mice.MethodsKunming-mice were randomly divided into four groups for the application of the vaseline ointment with different DEET concentrations (0,10%,20% and 30%). After the abdominal skin of the mice were smeared with those DEETs above mentioned and dipped into water for 10,30 min,1,2 h and 4 h, the mice were infected with (505) cercariae respectively. After infected for 6-7 weeks, all of the mice were sacrificed,and by perfusing heart the worms were collected and counted.Worm reduction rates were calculated and the rank sum tests were carried out. ResultsAt the time points of 1,2 and 4 h , the worm reduction rates were 78.34%,63.15% and 40.23% for 10% DEET vaseline ointment, 98.61%,93.37% and 75.74% for 20% DEET vaseline ointment and 100.00%,98.61% and 93.07% for 30% DEET vaseline oinment respectively(H =10.06,10.84,10.80,all P
