Cell proliferation and apoptosis in squamous carcinoma of cervix after neoadjuvant chemotherapy
- VernacularTitle:新辅助化疗对宫颈鳞癌细胞增殖与凋亡的影响
- Author:
Li WANG
;
Fenghua LIU
;
Ruonan LIU
- Publication Type:Journal Article
- Keywords:
cervical cancer;
neoadjuvant chemotherapy;
proliferating cell nuclear antigen;
apoptosis index
- From:Journal of Third Military Medical University
2003;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effect of neoadjuvant chemotherapy (NAC) for cervix cancer on cell proliferation and apoptosis. Methods A total of 24 patients with squamous carcinoma of the cervix (SCC) were treated with one cycle of cisplatin combined with hydroxycamptothecine, bleomycin regimen. The expression of proliferating cell nuclear antigen (PCNA) and apoptosis index (AI) were detected before and after NAC with flow cytometry and TUNEL. Results Clinical response was 58.3% (14/24). Before and after NAC, the expression of PCNA were (0.386?0.078) and (0.125?0.040) respectively and AI were (0.052?0.027) and (0.248?0.078). Significant difference of PCNA and AI could be observed before and after NAC (t=22.859, t=16.06, P
