Expression of VEGF and MMP9 in human ovarian carcinoma cell line SKOV_3 after carbon dioxide treatment
- VernacularTitle:二氧化碳气腹对人卵巢癌细胞株SKOV_3VEG F和MMP9表达的影响
- Author:
Junying TANG
;
Jin HUANG
;
Zhenwei YAO
- Publication Type:Journal Article
- Keywords:
carbon dioxide;
SKOV_3;
VEGF;
MMP9
- From:Journal of Third Military Medical University
2003;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of carbon dioxide on the metastatic capability of ovarian carcinoma cell line. Methods After ovarian carcinoma cells SKOV_(3) were treated with 100% carbon dioxide for 2 h, the expressions of VEGF and MMP9 were examined by immunohistochemistry and RT-PCR. Results After the treatment of carbon dioxide for 2 h, the expression of VEGF and MMP9 was significantly increased at 12~(th) h, the expression of VEGF reached the peak at 24~(th) h and the expression of MMP9 reached the peak at 48~(th) h. Conclusion Carbon dioxide may improve the metastatic capability of ovarian carcinoma cell line.
