A study on differences in vascular structure and function between spontaneous hypertension and metabolic syndrome in rat
- VernacularTitle:代谢综合征和自发性高血压大鼠血管结构及功能差异的研究
- Author:
Lili ZHANG
;
Lijuan WANG
;
Tingbing CAO
- Publication Type:Journal Article
- Keywords:
metabolic syndrome;
rats, inbred SHR;
artery injuries
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the features of vascular damage in metabolic syndrome (MS) by a comparison of changes in vascular structure and function between spontaneous hypertension (SH) and MS in rats. Methods Pathological study of changes in arteries was carried out. The contractile response of aorta ring and the expression of RhoA, ROCK, eNOS and iNOS were also determined. Results Besides the thickening of arterial wall and proliferation of both intima and smooth muscle layer, marked infiltration of inflammatory cell appeared in large and medium arteries of MS rats, and obvious hyaline degeneration was found in mesenteric arterioles. Moreover, the relaxant response of aorta ring was weakened markedly in MS rats, while the contractile response increased in SH rats dramatically. The expression of RhoA, ROCK increased and that of NOS decreased in MS rats, but the up-regulation of the RhoA, ROCK expression was not as much as in SH rats. Conclusion The damage to both arterial structure and function was much more serious in MS rats than that in SH rats. Activation of RhoA/ROCK system and reduction of NOS expression might be involved in the mechanism.
