Determination of vascular cell adhesion molecule-1 and lipid peroxides in aorta and plasma of Ins2~(Akita) diabetes mice
- VernacularTitle:糖尿病小鼠主动脉及血浆中血管细胞黏附分子-1和脂质过氧化水平的变化及意义
- Author:
Yingying WANG
;
Wei ZHANG
;
Weiling FU
- Publication Type:Journal Article
- Keywords:
diabetes mellitus, experimental;
mice, Ins2~ Akita;
vascular cell adhesion molecule-1;
lipid peroxidation
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the variation of vascular cell adhesion molecule-1 (VCAM-1) expression and lipid peroxidation in aorta and plasma of Ins2~ Akita diabetic mice, and to inquire into the relationship between the variation and the cardiovascular diseases in diabetic patients. Methods With the aortic and plasma samples from Ins2Akita diabetic mice, the protein expression levels of VCAM-1 were detected by Western Blot or ELISA, and the levels of lipid peroxides were determined by lipid peroxidation kit. Results Compared with that of normal control, VCAM-1 protein and lipid peroxides levels were significantly elevated in the aorta and plasma of Ins2~ Akita diabetic mice (P
