Observation of the effects of hemodialysis on endothelial cells.
- VernacularTitle:血液透析对血管内皮细胞影响的观察
- Author:
Yibin YANG
;
Zhongxia CHEN
;
Kun XU
- Publication Type:Journal Article
- Keywords:
Hemodialysis Endothelial cell von Willebrand factor
- From:
Chinese Journal of Practical Internal Medicine
2002;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of hemodialysis(HD) on the endothelial cells of the patients with end-stage renal disease(ESRD). Methods The study population consisted of 30 patients with undergoing first hemodialysis treatment and 20 healthy individuals from March to November of 2003.The number of circulating endothelial cells(CEC) and the concentration of von Willebrand factor(vWF) were measured in HD patients at predialysis,1h during HD,2h during HD,and the end of HD.CEC and vWF were observed in healthy subjects. Results CEC and vWF were increased in HD patients compared with healthy individuals,and elevated continuously during HD.Increased CEC and vWF were correlated significantly with duration of HD. Conclusion Endothelial cell dysfunction exists in the patients with ESRD.HD procedures may cause endothelial cell damage.
