Function of MAPKs signal transduction in synoviocytes with rheumatoid arthritis and the effect of drugs
- VernacularTitle:MAPKs信号转导在类风湿关节炎滑膜细胞中作用及其药物的影响
- Author:
Xiaoyi JIA
;
Yongqiu ZHENG
;
Wei WEI
- Publication Type:Journal Article
- Keywords:
MAPKs;
rheumatoid arthritis(RA);
synoviocytes;
drug treatment
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
The activation of MAPKs signal transduction parthways, is a typical feature of chronic synovitis in rheumatoid arthritis. The phosphorylation of synoviocytes cytoplasm proteins induced transcription factor and nucleus proteins phosphorylation such as c-fos, c-jun, AP-1 and NF-?B via MAPKs signal transduction, which promotes synoviocytes proliferation and activation. These findings may be beneficial for the elucidation of the pathogenesis and the development of new drugs for rheumatoid arthritis.
