Protective effect of ginsenoside Rb1 against H_2O_2-induced apoptosis in neonatal rat cardiomyocytes
- VernacularTitle:人参皂苷Rb1对H_2O_2诱导新生大鼠心肌细胞凋亡的保护作用
- Author:
Hao XU
;
Yakun GE
;
Tongle DENG
;
Tiannan WANG
;
Xiaoxiang ZHENG
- Publication Type:Journal Article
- Keywords:
ginsenoside Rb1;
cardiomyocytes;
hydrogen peroxide;
apoptosis;
calcium
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the protective effect of ginsenoside Rb1 against apoptosis induced by H_2O_2. Methods H_2O_2 was used to build an oxidative stress-induced injury model in neonatal rat cardiomyocytes. After treated with gensenoside Rb1(20, 40, 80 mg?L -1),the apoptosis rate, the content of malondialdehyde (MDA), and the activity of superoxide dimutase (SOD) of the cardiomyocytes were examined. The intracellular calcium indicated by the fluorescence in cells were measured by the laser confocal microscope. Results Compared with the model group, the apoptosis rate and the content of MDA of the cardiomyocytes decreased greatly (P
