Effects of Rh2 on cardiac hemodynamics and electrophysiological parameters in anesthetic rats

VernacularTitle:八厘麻毒素改造剂对麻醉大鼠的血流动力学及电生理作用
Author: Weiping YI ; Hanying QIU ; Hongtao CHU
Publication Type:Journal Article
Keywords: Rh2; hemodynamics; cardiac ventricle electrophysiology
From: Chinese Pharmacological Bulletin 2003;0(07):-
CountryChina
Language:Chinese
Abstract: Aim To observe the effects of Rh2 on the hemodynamics and electrophysiological parameters in anesthetic rats. Methods The changes of hemodynamics and electrophysiological parameters in anesthetic rats were tested after administration with Rh2, such as SAP, DAP, MAP, LVSP, LVDP, LVEDP, ?dp/dt_ max,HR,RRP and ERP. Results Rh2 increased SAP,DAP,MAP,LVSP,?dp/dt_ max with the decrease of LVEDP. It had no distinct effects on HR, ECG, RRP and ERP. Conclusion Rh2 has the effects of increasing SAP,DAP and MAP in anesthetic rats and has no influence on HR, ECG and cardiac ventricle electrophysiological parameter, suggesting that the effect of increasing blood pressure could be related to the increases of peripheral resistance.