Correlation between prognosis of spinal metastatic cancer and expression of matrix metalloproteinases and their inhibitors
- VernacularTitle:脊柱转移癌预后与基质金属蛋白酶及其抑制物表达的关系
- Author:
Huajiang CHEN
;
Yuli LI
;
Jianr XIAO
- Publication Type:Journal Article
- Keywords:
spine;
neoplasms, second primary;
matrix metalloproteinases;
tissue inhibitors of metalloproteinase
- From:
Academic Journal of Second Military Medical University
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the correlation between prognosis of spinal metastatic cancer and the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Methods: The expressions of MMPs and TIMPs were quantitatively studied by immunohistochemical method and image analysis technique in 77 patients with spinal metastatic cancer. The relation between MMPs and TIMPs expression and patients' prognosis was analyzed using Cox regression model. Results: The 3-year postoperative survival rate of the patients was 6.98% after a mean follow-up of 15.60?8.45 months ( 5.2-36 months). Both MMPs and TIMPs expressed in cancer cells and mesenchyme. The expression of MMP-2, TIMP-1 and TIMP-2 was the highest in the metastatic tumor from lung cancer (P
