Increase of thromboxane A_2 and prostacyclin in optic nerves after acute intraocular hypertension injury in rabbits
- VernacularTitle:兔眼急性高眼压对视神经血栓素A_2和前列环素的影响
- Author:
Canrong YAN
;
Xuanwei LIANG
;
Xiaojin FENG
;
Biao ZHENG
- Publication Type:Journal Article
- Keywords:
thromboxane A_2;
prostacyclin;
optic nerve;
ocular hypertension
- From:
Academic Journal of Second Military Medical University
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine the contents of thromboxane (TXA_2) and prostacyclin (PGI_2) in optic nerves after acute intraocular hypertension injury so as to provide experimental data for the treatment of the clinical intraocular hypertension. Methods: A rabbit acute intraocular hypertension injury model was established by 90-min anterior chamber douche. Thirty adult rabbits were equally randomized into 5 groups: 4 intraocular hypertension injury groups (60 min, 90 min, 24 h and 48 h after intraocular tension normalization) and a normal control group. The eyes of all rabbits were removed and the homogenate of optic nerves was used to determine the contents of TXB_2 and 6-Keto-PGF_ 1?, and the metabolites of TXA_2 and PGI_ 2 by radioimmunoassay. Results: The contents of TXB_2 and 6-Keto-PGF_ 1? in the 60 min and 90 min groups were significantly higher than those of the normal control group (P
