Association of serum protein S100b in intracerebral hemorrhage patients with nerve function lesion
- VernacularTitle:脑出血患者血清S100b蛋白与神经功能损害的相关性研究
- Author:
Qunfen LIAO
;
Desheng LIANG
;
Weimin WANG
;
Ning LIU
- Publication Type:Journal Article
- Keywords:
intracerebral hemorrhage;
protein S100b;
cranial computed tomography;
Chinese stroke score;
Barthel index score
- From:Journal of Third Military Medical University
2003;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum protein S100b in intracerebral hemorrhage (ICH) patients and brain damage. Methods A total of 37 hypertensive cerebral hemorrhage patients, 24 male and 13 female, were enrolled as intracerebral hemorrhage (ICH) group, aged from 45 to 85 years with an average of (69.2?8.9) years. The control group were matched with ICH group, including 30 healthy subjects, 19 male and 11 female, aged 52 to 70 (61.2?5.0) years. The concentration of serum protein S100 was detected using double antibody sandwich ELISA. Evaluation of blood volume was calculated with the fomula based on cranial CT data: V=S?L?Slice??/6. The nerve function of the patients was evaluated by the CSS during acute phase and Barthel index score at 3 month after stroke. Results Serum protein S100 concentration was significantly elevated in patients with ICH (0.54?0.41 ?g/L), as compared to controls (0.17?0.04 ?g/L)(P
