The effect of interferon ?-2a on the radiosensitivity for nasopharyngeal carcinoma cell line CNE-I
- VernacularTitle:干扰素?-2a对人鼻咽癌细胞株CNE-I放射敏感性的影响
- Author:
Guang LI
;
Yuxia ZHAO
;
Fei GU
- Publication Type:Journal Article
- Keywords:
Interferon;
Radiation-sensitizing agents;
Cell line,tumor
- From:
Chinese Journal of Radiation Oncology
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the effect of interferon ?-2a on the radiosensitivity and cell cycle for nasopharyngeal carcinoma cell line CNE-I. Methods Interferon ?-2a was given by different concentration. Then the cells were radiated with X-ray (6?MV) and the cell survival rate was calculated. The change of cell cycle dynamics was measured with flow cytometry. Results The cell survival fraction was 0.62, 0.43 and 0.20 respectively after the interferon ?-2a was given by different concentration(0.5?106, 1.0?106 and 1.5?106?IU/L). The radiosensitization ratio was 1.16, 1.57 and 1.93 respectively. Compared with the control group, increasing cell percentage in G_1 and G_2+M phage and decreasing cell percentage in S phage were observed on 24 h after the interferon ?-2a(1?106?IU/L) was given(P
