The synthesis and preliminary bioactivity of isoflavone derivatives
- VernacularTitle:异黄酮类衍生物的合成及其初步生物活性
- Author:
Hua HOU
;
Lingling WENG
;
Rong HU
- Publication Type:Journal Article
- Keywords:
isoflavone derivatives;
synthesis;
uterotrophic activities;
anti-uterotrophic activities
- From:Journal of Third Military Medical University
2003;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To synthesize soybean isoflavones, and their 7-alkaline analogues and to evaluate their uterotrophic activities and anti-uterotrophic activities preliminarily. Methods The target molecules were synthesized by multi-step from resorcinol and p-substituted phenylacetic acid as the starting material. Their uterotrophic activities and anti-uterotrophic activities were evaluated by female mouse at the concentration of 1.1?10 -2 ?mol/ml and 1.85?10 -3 ?mol/ml. Results Twenty-two compounds were synthesized, among which 4 intermediates and 12 isoflavones are new compounds. Conclusion All the target molecules except for 6a show weak uterotrophic activities and high anti-uterotrophic activities.
