Asthmatic epidemiological study of Han nationality in Chongqing
- VernacularTitle:中国重庆汉族哮喘遗传病例对照研究
- Author:
Qin GUI
;
Guisheng QIAN
;
Hongyan XIONG
;
Bo WU
- Publication Type:Journal Article
- Keywords:
asthma;
genetic epidemiology;
heritability;
relative risk
- From:Journal of Third Military Medical University
2003;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the genetic faction influence on asthmatic patients in Chongqing, China. Methods Case-control study was employed for genetic epidemiological survey. Results The heritability of asthma in Chongqing was (80.56?5.68)% in first-degree relatives of asthma probands. The segregation ratio was 0.18. The relative risk of first-degree relatives and siblings of asthma probands were 7.38 and 4.47, respectively. Conclusion The inheritance pattern of asthma in Chongqing coincided with polygenic inheritance pattern. Genetic factor is a major risk factor of asthma. The relative risk in siblings is high. We can localize the susceptible gene of asthma with positional cloning.
