Advances in the pathogenesis of shock
- VernacularTitle:重症难治性休克发生机制的若干进展
- Author:
Keseng ZHAO
- Publication Type:Journal Article
- Keywords:
mitochondria;
capillary no-reflow;
refractory hypotension;
hypoviscosaemia
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Irreversible shock is one of the major target in shock research. The dysfunction of mitochondria involves in the pathogenesis of shock and MODS. Capillary no-reflow post-treatment leads to decrease of functional capillary density (FCD), which is a predictor of bad prognosis. Refractory hypotension after treatment results in low perfusion of vital organ, which is also one of the causes for death. Hypovisosaemia is a problem in shock treatment with massive fluid infusion leading to the decrease of FCD and survival rate. The mechanisms of the issues mentioned above are discussed in the text.
