Influence of simvastatin on postprandial C-reactive protein concentrations in patients at high risk of cardiovascular event
- VernacularTitle:心血管事件高危患者餐后C反应蛋白质量浓度变化及辛伐他汀干预结果分析
- Author:
Weiji LIANG
;
Hongguang XIAN
;
Lei CHEN
- Publication Type:Journal Article
- Keywords:
Coronary disease Risk factors C-reactive protein Antilipemic agents
- From:
Chinese Journal of Practical Internal Medicine
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of postprandial plasma C-reactive protein(CRP)concentrations after a high-fat meal (800 calorie;50g fat) in patients at high risk of cardiovascular event,and explore the influence of simvastatin on CRP concentration in very short time. Methods 70 patients at high risk of cardiovascular disease were randomly divided into two groups to accept either simvastatin (20mg/d) (SIM group, n=36)or placebo (ROU group, n=34) at the base of routine therapy. All patients received an oral high-fat meal at baseline and one week later. The concentrations of plasma triglyceride(TG), total cholesterol, LDL-cholesterol, HDL-cholesterol and CRP in fasting state and at 4 hours postprandially were measured. Results The postprandial plasma TG and CRP concentrations increased significantly ( P
