Expression of tyrosine protein phosphatase 1B in adipose tissues of newly diagnosed diabetic patients
- VernacularTitle:蛋白酪氨酸磷酸酶1B在2型糖尿病初诊患者内脏脂肪组织的表达水平
- Author:
Miao WANG
;
Dajin ZOU
;
Jiong HOU
;
Jia ZHANG
- Publication Type:Journal Article
- Keywords:
protein tyrosine phosphatase 1B;
type 2 diabetes;
viscera;
adipose tissue;
insulin resistance;
obesity\
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the role of protein tyrosine phosphatase 1B(PTP-1B) in pathogenesis of type 2 diabetes. Methods: Thirty-four patients were divided into 3 groups: type 2 diabetes with normal BMI group(CDM), obese type 2 diabetes group (ODM) and control group. Fasting blood glucose, fasting insulin and body mass were determined. Expression of PTP-1B in adipose tissues were determined by Western blot. Results: Compared with control group, CDM and ODM groups had insulin resistance, though there was no significant difference between CDM and ODM groups. Expression of PTP-1B in control, CDM and ODM groups were 3.39?0.94,11.57?1.89 and 36.53?14.82, respectively. After controling for age and sex, expression of PTP-1B was positively related with BMI(r=0.67, P
