Indomethacin suppresses matrix metalloproteinase-9 expression in abdominal aortic aneurysm in rats
- VernacularTitle:吲哚美辛抑制大鼠腹主动脉瘤基质金属蛋白酶9表达的研究
- Author:
Shaojie JIANG
;
Zaiping JING
;
Xin ZHAO
- Publication Type:Journal Article
- Keywords:
aortic aneurysm, abdominal;
matrix metalloproteinase-9;
indomethacin
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the mechanism by which indomethacin inhibits the expression of matrix metalloproteinase-9 in abdominal aortic aneurysm(AAA) in rats. Methods: Male Wistar rats underwent intraluminal perfusion of the abdominal aorta with 50 units of porcine pancreatic elastase followed by treatment with indomethacin (1.6 mg/d) subcutaneously (n=8) for 7 d or with normal saline(NS,n=8).Aortic wall elastin and collagen concentrations were measured with an imaging analysis system, and fixed aortic tissues were examined by light microscopy for inflammation. The expression of MMP-9 in aortic tissues was observed with immunohistochemistry technique. Results: AAAs developed in all NS treated rats and in none of indomethacin treated rats on d 7(P
