Changes of platelets and coagulation function during cardiopulmonary bypass in patients undergoing cardiac valvular replacement surgery and effect of propofol on the changes
- VernacularTitle:体外循环下心瓣膜置换术患者血小板及凝血功能的变化及普鲁泊福对其的影响
- Author:
Ruoshan LIU
;
Wenzhong ZHU
;
Xiaoming DENG
;
Tao XU
- Publication Type:Journal Article
- Keywords:
cardiopulmonary bypass;
platelet;
blood coagulation;
propofol
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate changes of platelets and coagulation function in patients undergoing cardiac valvular replacement surgery during cardiopulmonary bypass(CPB).Methods: Thirty patients scheduled for elective cardiac valvular replacement were equally randomlized to 2 groups: control group and propofol group. In control group anesthesia was induced with midazolam 0.05 mg?kg -1,fentanyl 0.01 mg?kg -1 and vecuronium 0.1-0.2 mg?kg -1, and maintained with isoflurane,fentanyl and vecuronium. In propofol group anesthesia was induced with midazolam 0.05 mg?kg -1,fentanyl 0.005-0.01 mg?kg -1,propofol 1.5 mg?kg -1 and vecuronium 0.1-0.2 mg?kg -1, and propofol 4-5 mg?kg -1?h -1 was administered during operation with isoflurane,fentanyl and vecuronium. Blood samples were taken from jugular vein to assay SonACT, clot rate and platelet function with Sonoclot ananlysis, and to measure platelet count, PT and APTT before anesthesia, 5 min after induction,before CPB,10 min after CPB and at the end of operation.Results: Compared with those before anesthesia, PF, clot rate, platelet count, PT and APTT in both groups significantly decreased 10 min after CPB and at the end of operation(P
