Matrine sustained release tablet, capsule and injection: comparison of pharmacokinetics and relative bioavailability
- VernacularTitle:苦参碱缓释片、胶囊、注射液的药代动力学及生物利用度比较研究
- Author:
Yan LI
;
Weiwei CAO
;
Yanli YANG
;
Hao ZOU
;
Xueta JIANG
- Publication Type:Journal Article
- Keywords:
matrine;
sustained release tablet;
capsules injection;
pharmacokinetics;
biological availability
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the pharmacokinetics and relative bioavailability between matrine sustained release tablet,matrine conventional capsule and matrine injection. Methods: Dogs were given single oral dose and multiple doses of matrine sustained release tablet, capsule or injection in a randomized crossover way. Matrine concentrations in dog plasma were determined by RP-HPLC method. Results: The results showed that the t max and c max were 300 min and (5.088?0.490) ?g/ml for matrine sustained release tablet, (85?12) min and (6.360?0.215) ?g/ml for the conventional capsule, and 10 min and (6.500?0.404) ?g/ml for the injection. The relative bioavailability of the sustained release tablet was (153.7?9.4)% compared with that of the conventional capsule; the absolute bioavailability of the sustained release tablet was (73.5?14.2)% compared with that of the injecetion. The in vivo absorption rate of the sustained release tablet was significantly correlated with the in vitro release rate(r=0.981 2,P
