Renal involvement associated with antiphospholipid syndrome
- VernacularTitle:抗磷脂综合征的肾损害
- Author:
Ruitong GAO
- Publication Type:Journal Article
- Keywords:
Antiphospholipid syndrome;
Atibodies,antiphospholipida;
Kidney diseases
- From:
Chinese Journal of Nephrology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics of renal involvement associated with antiphospholipid syndrome (APS). Methods Data of 91 cases with APS who were admitted to our hospital from 1983 to 2004 were reviewed. Results Thirteen cases (14.3%) were primary APS (PAPS) and 78 cases (85.7%) were secondary APS(SAPS) including 55 cases with systemic lupus erythematosus. Renal involvement were found in 82 APS cases (90.1%). 76.9% patients with PAPS and 92.3% with SAPS had renal involvement. The average age of renal involvement was (38?14) years old. The ratio of male to female was 1:3.1 and the period of pre-renal damage was (4.9 ?6.8) years. The clinical manifestations included proteinuria (92.7%), gross hematuria (2.4%), microscopic hematuria (76.8%), hypertension (33.0%) and renal insufficiency(18.3%). Fourteen cases (15.4%)of acute renal insufficiency were caused by thrombotic microangiopathy, renal artery thrombosis, renal vein thrombosis and others. Kidney biopsy specimens were obtained from 8 patients with SLE,among them,5 (62.5%)had APS nephropathy and exhibited thrombosis of renal capillaries and renal small vessels, and fibrous intimal hyperplasia of renal interlobular arteries. Onion-peeled renal interlobular arteries were also found. Concolusions Renal involvements in APS are quite common, mainly including proteinuria, hematuria and hypertension. Thrombotic microangiopathy, renal artery thrombosis, renal vein thrombosis may occur and progress to acute renal insufficiency.
